She has played roles in independent mainstream events, films, and television series. Her first mainstream appearance was in 2005 when she worked as a red carpet reporter for the MTV Video Music Awards on MTV India. In 2011, she participated in the Indian reality television series Bigg Boss. She also has hosted the Indian reality show Splitsvilla.
In 2012 she made her Bollywood debut in Pooja Bhatt's erotic thriller Jism 2 (2012) and shifted her focus to mainstream acting which was followed up with Jackpot (2013), Ragini MMS 2 (2014) and Ek Paheli Leela (2015), One Night Stand (2016) and Tera Intezaar (2017).
Apart from her acting career she has been part of activism campaigns including the Rock 'n' Roll Los Angeles Half-Marathon to raise money for the American Cancer Society and has also posed for a People for the Ethical Treatment of Animals (PETA) ad campaign with a rescued dog, encouraging pet owners to have their cats and dogs spayed and neutered.
Since 2011, Leone has been married to musician Daniel Weber. She currently lives in Mumbai, Maharashtra.